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CHANGES IN RENAL RENIN GENE EXPRESSION IN FETAL SHEEP †
Author(s) -
Zhang David Yanling,
Lumbers Eugenie R.,
Simonetta Giuseppe
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb01758.x
Subject(s) - renin–angiotensin system , fetus , gene expression , gene , endocrinology , medicine , expression (computer science) , biology , physiology , pregnancy , genetics , blood pressure , computer science , programming language
SUMMARY 1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin and mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of renin gene expression were higher (178±5 units; P < 0.001) in foetuses at 142 days than levels in 91 (144±4 units) and 134 days old foetuses (146±6 units). 5. It is concluded that the high level of renin gene expression in the foetal kidney in responsible for the high levels of renin in the foetal circulation.