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COSEGREGATION OF THE NEW REGION ON CHROMOSOME 3 WITH SALT‐INDUCED HYPERTENSION IN FEMALE F2 PROGENY FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE AND WISTAR‐KYOTO RATS
Author(s) -
Matsumoto Chiho,
Nara Yasuo,
Ikeda Katsumi,
Tamada Tomoko,
Mashimo Tomoji,
Nabika Toru,
Sawamura Makoto,
Yamori Yukio
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb01163.x
Subject(s) - blood pressure , endocrinology , medicine , chromosome , diastole , biology , hormone , stroke (engine) , gene , salt (chemistry) , essential hypertension , genetics , chemistry , mechanical engineering , engineering
SUMMARY 1. We investigated candidate loci for salt‐sensitive high blood pressure (BP) in F2 progeny from crossing Wistar‐Kyoto and stroke‐prone spontaneously hypertensive rats. 2. In female F2 progeny, systolic and diastolic BP on the 12th day and the seventh month after salt loading was strongly liked with the D3Mgh12 and D3Mgh6 loci on chromosome 3, respectively. 3. These loci were linked with BP only in female F2 progeny, not in males. 4. These results indicate that hormonal factors may influence salt sensitivity, particularly with respect to gender differences.