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PHOSPHODIESTERASE INHIBITORS AND ENDOTHELIN AS MODULATORS OF RESPIRATORY NEUROTRANSMISSION
Author(s) -
Fernandes LB
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb01153.x
Subject(s) - cholinergic , phosphodiesterase , guinea pig , adrenergic , endothelin receptor , pharmacology , endothelin 1 , medicine , respiratory system , endocrinology , biology , receptor , enzyme , biochemistry
SUMMARY 1. Airway smooth muscle receives cholinergic, adrenergic and non‐adrenergic, non‐cholinergic (NANC) neural input. In guinea‐pig airways cholinergic and NANC nerves provide contractile innervation, while adrenergic and NANC nerves provide nerves provide relaxant pathways. In contrast, the major relaxant innervation in human airways is NANC in nature. 2. The present review describes the effects of selective phosphodiesterase (PDE) inhibitors on NANC relaxant and contractle responses in guinea‐pig trachea as well as on NANC relaxations in human bronchus. 3. The effects of endothelin‐1 on cholinergic contractile responses obtained in a variety of species are also assessed.