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PHENYTOIN‐INDUCED HYPERGLYCAEMIA MAY CONFOUND RAT CEREBROPROTECTION MODELS
Author(s) -
Qi Hui,
Newman George C.
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb01140.x
Subject(s) - phenytoin , hypothermia , neuroprotection , anticonvulsant , medicine , ischemia , bradycardia , animal model , pharmacology , endocrinology , epilepsy , anesthesia , blood pressure , heart rate , psychiatry
SUMMARY 1. The anticonvulsant phenytoin (PHT) has been used with variable success in animal models of cerebral ischaemia. Although PHT has been reported to alter glucose regulation in man, this potential effect has been largely ignored in animals. Because hyperglycaemia strongly influences the outcome of cerebral ischaemia, we sought to systematically delineate the effects of PHT on serum glucose in several rat strains. 2. We have studied the PHT dose‐response curve for serum PHT and glucose concentrations and several physiological variables. Phenytoin induces a significant, concentration‐dependent hyperglycaemia, even in the ranges commonly used for humans and in animal models. 3. Hypothermia of several degrees was observed during PHT administration, but no hypotension or bradycardia was found. 4. Both hyperglycaemia and hypothermia must be considered when PHT is studied as a neuroprotective agent in animal models.