Premium
ROLE OF RENAL DOPAMINERGIC ACTIVITY ON RENAL SODIUM‐WATER METABOLISM IN CONGESTIVE HEART FAILURE
Author(s) -
Hayashi Manabu,
Shimamoto Kazuaki,
Tsuchihashi Kazufumi,
Ishiguro Toshiya,
Torii Takaaki,
Sawai Niroh,
Mukai Hiroya,
Iimura Osamu
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb01136.x
Subject(s) - fractional excretion of sodium , medicine , heart failure , endocrinology , dopamine , excretion , kidney , renal function , ejection fraction , creatinine , dopaminergic , chemistry , free water clearance
SUMMARY 1. The role of the renal dopaminergic system in water‐sodium metabolism in heart failure remains unclear. 2. In this study, the urinary free dopamine excretion (uDA), delivery of l ‐dopa X creatinine clearance (Cer)), and the production of dopamine in the kidney [uDA/(plasma l ‐dopa x Cer)] were investigated in patients with congestive herat failure (n= 30) and in normal controls (n = 12). In both groups, endogenous Ccr, urinary excretion of sodium (UNaV), fractional excretion of sodium (FENa), plasma noradrenaline concentration (pNA) and plasma l ‐dopa and dopamine production in the kidney showed successively lower values in congestive heart failure with progression in NYHA functional class. 4. UNaV (r = 0.48, P < 0.05) and Cer (r = 0.539, P < 0.01) positively correlated with uDA. Linear correlations were found between left ventricular ejection fraction and uDA (r = 0.574, P < 0.01), pNA)r = ‐0.495, P < 0.01) or plasma l‐dopa (r = 0.423, P < 0.05). 5. From these findings, it was suggested that (i) uDA was clearly suppressed in patients with CHF, and (ii) the possible mechanisms of its suppression might be due to decrease of delivery of l ‐dopa into the proximal tubulles and suppressed production of dopamine from l ‐dopa in the kidney.