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α 1 ‐ADRENOCEPTOR SUBTYPES MEDIATING THE CONTRACTION OF ARTERIES IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Fujimoto S.,
SumiFujimoto K.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02983.x
Subject(s) - contraction (grammar) , femoral artery , aorta , medicine , schild regression , artery , endocrinology , blood vessel , spontaneously hypertensive rat , adrenergic receptor , chemistry , anatomy , blood pressure , antagonist , receptor
Summary 1. This study was undertaken to determine which (α 1 ‐adrenoceptor (AR) subtypes were involved in the activation of the femoral artery and the aorta by norepinephrine (NE) in spontaneously hypertensive rats (SHR). 2. Negative log EC 50 values and maximum responses of NE‐induced contraction of the SHR femoral artery were unchanged and increased, respectively, compared with those of Wistar‐Kyoto (WKY) rats. 3. Contractile responses of the SHR aortas to NE were similar to those of the normotensive tissues. 4. Schild plot data for cut‐AR antagonists indicated that α 1 ‐AR in the aorta were predominantly α 1H subtype. In the femoral artery, because Schild plots for bunazosin had slopes of less than 1.0, there were α 1H (or α 1C ) and α 1L subtypes. 5. The α 1 ‐AR subtype in the aorta was essentially identical to the α 1H subtype in the femoral artery. α 1 ‐AR subtypes mediating contraction in the SHR blood vessels were identical to those in the WKY tissues.