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BARORECEPTOR FUNCTION IS RESTORED BY ANTIHYPERTENSIVE THERAPY THROUGH LOWERING OF BLOOD PRESSURE IN ADULT SHR
Author(s) -
Ichikawa Masashi,
Suzuki Hiromichi,
Kumagai Kazuhiro,
Ryuzaki Munekazu,
Kumagai Hiroo,
Nishizawa Masahiko,
Saruta Takao
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02973.x
Subject(s) - baroreceptor , blood pressure , medicine , cardiology , pharmacology , heart rate
Summary 1. We investigated the effects of antihypertensive treatment (8 weeks) with four different agents (trichlormethiazide, atenolol, nicardipine and enalapril) on baroreceptor function in 28 week old spontaneously hypertensive rats (SHR) to measure aortic depressor nerve (ADN) activity. 2. Threshold pressure (P th ) of ADN activity was elevated and the gain sensitivity of the pressure–‐activity curve, as determined by the maximum gain (G max ) of a logistic function curve, was depressed in untreated SHR compared to those in untreated Wistar‐Kyoto (WKY) rats. 3. Treatment with the four agents similarly reduced blood pressure in SHR. Each of the four agents induced a decrease in P th and an increase in G max to a similar extent in SHR. 4. These findings suggest that antihypertensive therapy in chronic hypertension augments baroreceptor function through the lowering of blood pressure but not through specific pharmacological actions.