Premium
FUNCTIONAL ALTERATION OF THE GABA B RECEPTOR IN THE BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Ichida Tatsuya,
Sasaki Susumu,
Takeda Kazuo,
Kuriyama Kinya,
Nakagawa Masao
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02967.x
Subject(s) - gabab receptor , medicine , endocrinology , receptor , baclofen , spontaneously hypertensive rat , chemistry , adenylate kinase , hypothalamus , cyclase , gabaa receptor , blood pressure , agonist , biology
Summary 1. We studied the ontogenetic development of GABA B receptors and their coupling to cyclic AMP formation in spontaneously hypertensive (SHR) and normotensive Wistar‐Kyoto (WKY) rat brains. GABA B receptor binding to various brain regions was compared in age‐matched SHR and WKY rats. 2. The specific [ 3 H]‐GABA binding to the posterior hypothalamus (PH) was significantly lower in not only 4 week old (normotensive) but also 11 week old (hypertensive) SHR, when compared with age‐matched WKY. 3. Moreover, GABA B receptor agonists (baclofen and DN‐2327)‐induced suppression of adenylate cyclase activity also showed a decrease in 4 week old and 11 week old SHR PH. 4. We concluded that the number and the functional responsiveness of GABA B receptors in rat brains decrease in SHR, preceding blood pressure elevation. The activity of GABA B ergic mechanisms may be different in the brains of SHR and WKY rats.