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PROTECTIVE EFFECT OF THROMBOXANE SYNTHETASE INHIBITOR ON HYPERTENSIVE RENAL DAMAGE IN DAHL SALT‐SENSITIVE RATS
Author(s) -
Gomi T.,
Ikeda T.,
Sasaki Y.,
Kosugi T.,
Shibuya Y.,
Sakurai J.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02959.x
Subject(s) - pharmacology , thromboxane , thromboxane a synthase , chemistry , medicine , renal injury , endocrinology , kidney , platelet
Summary 1. The effects of OKY‐046, a specific thromboxane (TX) synthetase inhibitor, on blood pressure, urinary excretion of TX and its release from blood platelets and renal papilla, and pathological change of glomeruli were evaluated in Dahl salt‐sensitive rats. 2. Average daily intakes of OKY‐046‐treated rats were 0.93 mg/kg (low dose), 9.8mg/kg (moderate dose), and 88 mg/kg (high dose). 3. Systolic blood pressure tended to decrease by 6.3, 11.4, and 10.9% in three OKY‐treated groups. 4. OKY‐046 suppressed the release of TX from platelets in a dose‐dependent fashion. Both TX in urine and released from renal papilla decreased in OKY‐treated groups with moderate and high dose. OKY‐046 resulted no change in urinary excretion or release from renal papilla of prostaglandin E 2 or 6‐keto‐prostaglandin F 1α . 5. Glomerular sclerosis score decreased significantly in both groups treated with moderate and high doses of OKY‐046. 6. An inhibition of renal TX synthesis by TX synthetase inhibitor has a protective effect on the development of hypertensive renal damage with minor antihypertensive effect in Dahl salt‐sensitive rats.