Premium
DO KININS MEDIATE CARDIOPROTECTIVE AND RENOPROTECTIVE EFFECTS OF CILAZAPRIL IN SPONTANEOUSLY HYPERTENSIVE RATS WITH RENAL ABLATION?
Author(s) -
Kohzuki Masahiro,
Yasujima Minoru,
Kanazawa Masayuki,
Yoshida Kazunori,
Sato Tokutato,
Abe Keishi
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02953.x
Subject(s) - cilazapril , endocrinology , medicine , blood pressure , nephrectomy , creatinine , kinin , angiotensin converting enzyme , excretion , kidney , chemistry , ace inhibitor , bradykinin , receptor
Summary 1. We assessed the potential of the kallikrein–‐kinin system in mediating the cardioprotective and renoprotective effects of an angiotensin‐converting enzyme inhibitor (ACEI), cilazapril (CIL) in rats with renal ablation. 2. Eight week old spontaneously hypertensive rats (SHR) were subjected to 5/6 nephrectomy. One week after the operation, the rats were divided into 5 groups: (i) vehicle; (ii) CIL 1 mg/kg per day per os (p.o.); (iii) Hoe140 (HOE) 70 μg/kg per day given intraperitoneally (i.p.); (iv) CIL 1 mg/kg per day p.0. plus HOE 7 7μg/kg per day i.p.; (v) CIL 1 mg/kg per day p.o. plus HOE 70 μg/kg per day i.p. The treatment lasted for 4 weeks. 3. CIL alone significantly reduced systolic blood pressure, urinary protein excretion, heart weight and serum creatinine level. HOE alone did not induce any significant changes in these parameters. CIL in combination with HOE (7 or 70 μg/kg per day) did not induce any changes in these parameters, in addition to those associated with the effects of CIL alone. 4. These results indicate that the kallikrein‐kinin system might not play a major role in the cardioprotective and renoprotective effects of ACE inhibitors in the rat remnant kidney model of chronic renal failure.