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EFFECTS OF (‐)‐EPIGALLOCATECHIN‐3‐O‐GALLATE (GREEN TEA TANNIN) ON THE LIFE SPAN OF STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Uchida S.,
Ozaki M.,
Akashi T.,
Yamashita K.,
Niwa M.,
Taniyama K.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02928.x
Subject(s) - tannin , epigallocatechin gallate , life span , stroke (engine) , gallate , traditional medicine , green tea , catechin , chemistry , food science , medicine , polyphenol , pharmacology , biochemistry , antioxidant , gerontology , physics , thermodynamics
Summary 1. Effect of (‐)‐epigallocatechin‐3‐O‐gallate (EGCG), a condensed tannin isolated from green tea leaves, on the life span and hypertensive lesions in the stroke‐prone spontaneously hypertensive rat (SHRSP) was compared with that of persimmon tannin. 2. Long‐term administration of either 0.5% EGCG or 0.5% persimmon tannin to SHRSP inhibited the incidence of stroke and prolonged the life span, but did not affect the blood pressure. 3. These results indicate that EGCG may prevent incidence of stroke due to the radical scavenging action and inhibition of lipid peroxidation, and may result in prolonging the life span of SHRSP, as in the case of persimmon tannin.