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TEMPORAL AND SPATIAL PROPERTIES OF SLOW WAVES IN THE ELECTROENCEPHALOGRAM OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Chichibu Shiko,
Ohta Yoshio,
Chikugo Takaaki,
Suzuki Tsuneyuki
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02921.x
Subject(s) - electroencephalography , medicine , period (music) , stroke (engine) , neuroscience , spectral analysis , cardiology , endocrinology , psychology , physics , quantum mechanics , spectroscopy , acoustics , thermodynamics
Summary 1. Electroencephalogram (EEG) of stroke‐prone spontaneously hypertensive rats (SHRSP) and M(malignant)‐SHRSP were analysed for excitability changes in the cerebral neuronal circuit using power spectral comparisons. 2. EEG in hypertensive SHRSP and M‐SHRSP showed the emergence of slow wave bursts parallel to the development of hypertension. 3. These bursts were composed of spikes and sharp waves, and became dominant in the later stages of hypertension. 4. Bursts were interposed by a silent period indicating a strongly depressed state of neuronal activities. The ratio of the periods of the depressed to the burst increased with the progress of the hypertension. 5. A shift of the major component toward a lower frequency band also indicated decreased cerebral activity.