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STUDIES ON PREGNANCY HYPERTENSION AND IUGR‐SFD EFFECTS OF DRUGS ON THE BLOOD VESSELS IN THE PLACENTA OF PREGNANT SHRSP
Author(s) -
Fuchi Isao,
Noda Kiichiro,
Matsubara Yoshiharu
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02920.x
Subject(s) - placenta , medicine , pregnancy , spiral artery , obstetrics , uterine artery , blood pressure , fetus , gestation , biology , genetics
Summary 1. Based upon our previous work, we came to the conclusion that a decrease in placental blood volume was a possible factor behind intrauterine growth retardation (IUGR) in pregnancy‐induced hypertension. 2. In a second study, we used an image analysis system to measure cross‐sectional areas and wall thicknesses of central blood vessels of the spiral artery, the so‐called ‘central artery’. 3. It was thought that one of the more basic factors behind IUGR in pregnancy‐induced hypertension might possibly be narrowings and spasms of the maternal placental blood vessels. 4. In this study, we found that the three drugs we used (MgSO 4 .7H 2 O, Solcoseryl and KCl) all resulted in an enlargement of the cross‐sectional areas of the maternal blood vessels, and that MgSO 4 .7H 2 O, in particular, also relaxed maternal blood vessel spasms in SHRSP placenta.