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FIBRINOLYTIC ACTIVITY IN LIVER TISSUES OF STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Okada Kiyotaka,
Yuasa Haruyuki,
Hagiya Yasuhiro,
Takaishi Tomoaki,
Fukao Hideharu,
Ueshima Shigeru,
Matsuo Osamu
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02914.x
Subject(s) - lytic cycle , liver tissue , tissue plasminogen activator , medicine , endocrinology , stroke (engine) , plasminogen activator , spontaneously hypertensive rat , chemistry , fibrin , immunology , blood pressure , mechanical engineering , virus , engineering
Summary 1. Plasminogen activator activity was detected in the extract solution of the liver tissues of both stroke‐prone spontaneously hypertensive rats (SHRSP) and Wistar‐Kyoto (WKY) rats by the synthetic substrate assay. 2. The total PA activity in the liver extract of WKY (26.8 ± 8.3 i.u.) was about 1.5‐fold higher than that of SHRSP (18.5 ± 4.1 i.u., n = 8, P < 0.005). 3. The enzymography of the liver extract revealed three lytic bands with a molecular weight of 67 kDa, 44 kDa and 38 kDa. 4. The inhibitor activity of the liver extract was detected by the reverse fibrin autography method with one lytic resistance hand at 70 kDa. 5. Thus, fibrinolytic components exist in the liver tissue of both strains of rats, but their contribution to the stroke requires further study.