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COMPARISON OF THE EFFECTS OF HYPERCHOLESTEROLAEMIA ON RELAXATION RESPONSES IN AORTAS OF SPONTANEOUSLY HYPERTENSIVE RATS AND DAHL SALT‐SENSITIVE RATS
Author(s) -
Kitagawa S.,
Sameshima E.,
Yamaguchi Y.,
Kwon Y.,
Shinozuka K.,
Kunitomo M.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02904.x
Subject(s) - sodium nitroprusside , medicine , endocrinology , aorta , cholesterol , blood pressure , relaxation (psychology) , spontaneously hypertensive rat , endothelial dysfunction , thoracic aorta , acetylcholine , endothelium , chemistry , nitric oxide
Summary 1. We investigated the effects of hypercholesterolaemia on relaxation responses in thoracic aortas isolated from two different types of hypertensive rats; spontaneously hypertensive rats (SHR) and Dahl salt‐sensitive rats (DSR). 2. All rats fed the high cholesterol diet for 8 weeks showed a significant increase in the serum cholesterol level. The high‐cholesterol diet did not change the blood pressure of SHR, but increased that of hypertensive DSR fed a high‐salt diet. 3. In aortas of SHR, the high‐cholesterol diet did not change the endothelium‐dependent and ‐independent relaxation induced by acetylcholine (ACh) and sodium nitroprusside (SNP), respectively. 4. In aortas of hypertensive DSR, the high‐cholesterol diet notably reduced the ACh‐induced relaxations and slightly reduced SNP‐induced relaxation. 5. These results suggest that hypercholesterolaemia causes greater impairment of endothelium‐dependent relaxation in rat aorta with salt‐induced hypertension than genetic hypertension.