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DECREASED EXPRESSION OF THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR mRNA IN THE CARDIAC VENTRICLE OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Jingami H.,
Masuzaki H.,
Matsuoka N.,
Nakagawa O.,
Ogawa Y.,
Mizuno M.,
Yamamoto T.,
Nakao K.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02902.x
Subject(s) - medicine , endocrinology , very low density lipoprotein , ventricle , ldl receptor , receptor , adipose tissue , lipoprotein , muscle hypertrophy , chemistry , biology , cholesterol
Summary 1. To elucidate the functional implication of very low density lipoprotein (VLDL) receptor, we studied the gene expression of VLDL receptor in rats. The VLDL receptor mRNA was highly expressed in the cardiac ventricle and skeletal muscle. Intermediate amounts of VLDL receptor mRNA were detected in adipose tissue, adrenal gland, brain and lung. Thus the tissue distribution of VLDL receptor mRNA in rats was similar to that reported previously in rabbits. 2. We studied the gene expression of the VLDL receptor in the heart of stroke‐prone spontaneously hypertensive rats (SHRSP), an animal model for hypertension‐induced cardiac hypertrophy. RNase protection assay showed that the level of ventricular VLDL receptor mRNA was already decreased to one half when hypertension was not fully developed, and further diminished to one fifth when cardiac hypertrophy was established. 3. It is reported that energy utilization in SHRSP hypertrophied myocardium is impaired. Our results suggest that inactive fatty acid metabolism in the ventricle of SHRSP is related to the lowered expression of the VLDL receptor which is postulated as a gate for triglyceride‐rich lipoprotein particle.