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AUGMENTED Ca 2+ MOBILIZATION IS A HYPERTENSIVE TRAIT DISCRIMINATED FROM A ‘MAJOR GENE’ IN BACKCROSS ANALYSIS BETWEEN SHR AND DONRYU RATS
Author(s) -
Ohno Yoichi,
Suzuki Hiromichi,
Matsuo Koichi,
Tanase Hisao,
Takano Toshiya,
Saruta Takao
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02890.x
Subject(s) - backcrossing , blood pressure , medicine , mobilization , quantitative trait locus , endocrinology , normal group , gene , biology , chemistry , genetics , history , archaeology
Summary 1. Blood pressure and Ca 2+ mobilization were significantly greater in SHR than in Donryu and F 1 rats. 2. Backcross linkage analysis between spontaneously hypertensive rats and normotensive Donryu rats was performed to dissect polygenic hypertensive traits and to detect the existence of a single ‘major gene’. 3. Cluster and discriminant analysis of a scattergram of blood pressure versus Ca 2+ mobilization classified the back‐crossed rats into two groups. The two groups were referred to the higher group and the lower group with regard to their relative blood pressure values. 4. Blood pressure was correlated with Ca 2+ mobilization in each group; the correlation coefficients were 0.41 for the higher group ( P < 0.01) and 0.71 for the lower group ( P < 0.0001).