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MAGNESIUM, CALCIUM AND TRACE ELEMENTS IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Saito Noboru,
Abbu G. C.,
Konishi Yuuko,
Nishiyama Shoji,
Okada Teruhiko
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02887.x
Subject(s) - magnesium , calcium , endocrinology , medicine , selenium , chemistry , organic chemistry
Summary 1. Using three strains, which showed severe hypertension, mild hypertension and normotension, respectively, the relationships between electrolytes or trace elements and vascular complications combined with the factor of ageing were investigated. 2. In ash materials of some tissues old female SHRSP and old WKY showed a decrease of selenium in many tissues when compared to adult female SHRSP and WKY, respectively. 3. In cellular supernatant fraction, SHRSP showed a decrease of magnesium in many tissues and an elevation of the calcium to magnesium ratio when compared to age‐matched WKY and SHRSR. 4. In diabetic rats induced by streptozotocin, myocardial magnesium decreased, resulting in an elevation of the myocardial calcium to magnesium ratio. 5. Alpha tocopherol concentration was lower in both the myocardium and cerebrum of old female SHRSR when compared to that of adult female SHRSR. 6. From these findings the elevation of calcium to magnesium ratio was found in old rats and SHRSP, indicating the tendency of tissue deterioration in these rats. 7. Tissue selenium also decreased in old rats and SHRSP and this decrement was probably related to the peroxidation in tissue damage.