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LIPID MEDIATORS AND PROTEIN KINASE C FOR INTRACELLULAR SIGNALLING
Author(s) -
Nishizuka Yasutomi,
Nakamura Shunichi
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02883.x
Subject(s) - intracellular , microbiology and biotechnology , protein kinase a , kinase , chemistry , stimulation , protein kinase c , lipid signaling , signal transduction , receptor , ask1 , biochemistry , mitogen activated protein kinase kinase , biology , endocrinology
Summary 1. The stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. 2. Many of their metabolites have potentials to induce, intensify and prolong the activation of protein kinase C that is needed for sustained cellular responses.