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INFLUENCE OF HYPERTENSIVE VASCULAR CHANGES IN INTRATESTICULAR ARTERIES ON SPERMATOGENESIS IN SHRSP
Author(s) -
Itoh Naoki,
Akagashi Keigo,
Kumamoto Yoshiaki,
Suzuki Tsuneyuki,
Ohta Yoshio
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02852.x
Subject(s) - medicine , endocrinology , sertoli cell , spermatogenesis
Summary 1. The process of the spermatogenetic damage induced by hypertensive vascular changes was studied with stroke‐prone spontaneously hypertensive rats (SHRSP). 2. In SHRSP, hypertensive changes in intratesticular arterioles developed from 19 weeks of age. 3. At 23 weeks of age, a severe reduction in the number of mature and immature spermatids was observed. 4. The transferrin concentration in testicular cytosol was decreased at 23 weeks of age, suggesting that Sertoli cell function in SHRSP had regressed. 5. In conclusion, it was suggested that the decline in Sertoli cell function as a result of hypertensive vascular changes is part of the mechanism whereby spermatogenic damage occurs in SHRSP.