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SOME PHYSIOLOGICAL OUTCOMES OF RENIN GENE STUDIES
Author(s) -
Moris Brian J.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02334.x
Subject(s) - renin–angiotensin system , pathophysiology , gene , endocrinology , biology , gene expression , medicine , disease , cloning (programming) , plasma renin activity , bioinformatics , genetics , blood pressure , computer science , programming language
SUMMARY 1. The cloning of the renin gene has permitted studies of its physiological regulation, extrarenal expression and role in disease. 2. Marked modulation of renin mRNA concentration is seen in adrenal, heart and hypothalamus in response to sodium depletion and inhibition of A11 formation, as well as in models of renal and genetic hypertension in the rat. 3. One important outcome of studies of the promoter has been the discovery of a cyclic AMP‐responsive sequence. 4. Sequence variations have been detected in or near the renin gene and have been used as markers in studies of its role in cardiovascular disease aetiology. 5. In conclusion, molecular biology has, in the past decade, made a significant contribution to the understanding of renin physiology and pathophysiology.