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PROLACTIN INDUCED ANALGESIA IS DEPENDENT ON ATP SENSITIVE POTASSIUM CHANNELS
Author(s) -
Shewade D. G.,
Ramaswamy S.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02079.x
Subject(s) - glibenclamide , minoxidil , prolactin , potassium channel , atp sensitive potassium channel , analgesic , pharmacology , potassium channel opener , chemistry , potassium channel blocker , morphine , potassium , endocrinology , medicine , hormone , organic chemistry , diabetes mellitus
SUMMARY 1. The role of ATP sensitive potassium channels in the analgesic activity of prolactin (PRL) was studied in mice using glibenclamide and minoxidil, a blocker and an opener of these channel, respectively. 2. Re‐treatment with glibenclamide attenuated the analgesic activity of PRL while treatment with minoxidil potentiated the activity. 3. It is concluded that PRL, similar to morphine, utilizes ATP sensitive potassium channels in eliciting the analgesic response.