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WHOLE BODY AND RENAL NORADRENALINE RELEASE DURING ACUTE INFUSION OF ENDOTHELIN‐1 IN CONSCIOUS SHEEP
Author(s) -
Mathai Michael L.,
Whitworth Judith A.,
McDougall John G.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02077.x
Subject(s) - endothelin receptor , medicine , endocrinology , anesthesia , receptor
SUMMARY 1. The present study investigated in conscious sheep the response of the sympathetic nervous system to a systemic infusion of 20 nmol/h endothelin‐1 (ET‐l), using a tritiated‐noradrenaline (NA) tracer dilution technique. 2. Mean arterial pressure increased from 79 ±3 mmHg to a maximal level of 102± 12 mmHg by 30 min of ET‐1 infusion. 3. Total and renal NA kinetics were measured during this time. Total NA spillover was not affected by infusion of ET‐1. In contrast, renal NA spillover decreased from a control level of 81 ± 5 to 30 ± 14ng/min ( P <0.01) after 20 min and to 27 ± 7ng/min ( P <0.01) after 30 min of ET‐1 infusion. 4. The present findings are consistent with the proposal that a direct vasoconstrictor action of ET‐1 results in a paroreflex mediated reduction in renal sympathetic vasoconstrictor activity.