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CROSS‐SECTIONAL STUDY OF A MICROSATELLITE MARKER IN THE LOW DENSITY LIPOPROTEIN RECEPTOR GENE IN OBESE NORMOTENSIVES
Author(s) -
Griffiths Lyn R.,
Nyholt Dale R.,
Curtain Robert P.,
Gaffney Philip T.,
Morris Brian J.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02056.x
Subject(s) - ldl receptor , obesity , medicine , endocrinology , genotype , lipoprotein , polymorphism (computer science) , population , cholesterol , biology , gene , genetics , environmental health
SUMMARY 1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene ( LDLR ) dinucleotide polymorphism were determined in both lean and obese normotensive populations. 2. In previous cross‐sectional association studies an Apa LI and a Hinc II polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives. 3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3’ end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.