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EFFECTS OF ISOTONIC SALINE LOADING ON RENAL TUBULAR AND NEUROGENIC DOPAMINE RELEASE IN CONSCIOUS RABBITS
Author(s) -
Akama Hiroyoshi,
Noshiro Takao,
Sane Naoki,
Watanabe Toshiya,
Trigg Lisbeth,
Kotsonis Peter,
Majewski Harry,
McGrath Barry P.,
Miura Yukio,
Abe Keishi
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02047.x
Subject(s) - isotonic saline , saline , isotonic solutions , endocrinology , medicine , isotonic , sodium , excretion , chemistry , natriuresis , renal blood flow , renal circulation , kidney , organic chemistry
SUMMARY 1. This study was designed to investigate the effects of isotonic saline loading on renal tubular and neurogenic dopamine (DA) in conscious rabbits. 2. Isotonic saline loading did not affect mean arterial pressure, heart rate or renal blood flow but markedly increased urine volume, sodium excretion and DA excretion. 3. Renal DA spillover was not affected by venous emptying, while renal noradrenaline (NA) spillover tended to decrease during saline loading. The ratio of % renal DA spillover to % renal NA spillover increased to 2.3 ± 0.6 ( P < 0.05) 3h after saline loading. 4. Isotonic saline loading increased renal tubular DA production but had little effect on neurogenic DA release.