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INVOLVEMENT OF OXIDATIVE AND L‐ARGININE‐NO PATHWAYS IN THE NEUROTOXICITY OF DRUGS OF ABUSE IN VITRO
Author(s) -
Cerruti C.,
Sheng P.,
Ladenheim B.,
Epstein C. J.,
Cadet JL.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02025.x
Subject(s) - neurotoxicity , arginine , in vitro , pharmacology , oxidative damage , chemistry , oxidative phosphorylation , drugs of abuse , oxidative stress , medicine , toxicology , biochemistry , biology , toxicity , drug , amino acid
SUMMARY 1. Inhibitors of nitric oxide (NO) formation or ADP‐ribosylation attenuate methamphetamine (METH)‐ and methyl‐enedioxymetamphetamine (MDMA)‐induced neurotoxicity on dopaminergic and serotonergic cells in primary cultures. 2. They also prevent METH‐induced reactive gliosis in dopaminergic cultures. 3. Overexpression of superoxide dismutase (SOD) in cells obtained from SOD‐transgenic mice also attenuates drug‐induced toxicity. 4. These data indicate a role for oxygen‐based and NO free radicals in the mechanisms of cell death associated with drugs of abuse in vitro .