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ALTERATION OF THE MORPHOLOGY AND NEUROCHEMISTRY OF THE DEVELOPING MAMMALIAN NERVOUS SYSTEM BY HYDROGEN SULPHIDE
Author(s) -
Roth S. H.,
Skrajny B.,
Reiffenstein R. J.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02024.x
Subject(s) - toxicant , monoamine neurotransmitter , neurochemistry , central nervous system , biology , medicine , nervous system , neuroscience , endocrinology , physiology , serotonin , toxicity , neurology , receptor
SUMMARY 1. Hydrogen sulphide (H 2 S) is a broad spectrum toxicant that occurs widely in nature and is also released by a variety of industrial activities and processes. 2. The central nervous system (CNS) appears to be the major target organ. 3. There is great potential for insult or injury to the developing or immature CNS. 4. The risks of chronic or repeated exposures to low concentrations have not been well defined. 5. Exposure to low concentrations of H 2 S to time‐pregnant rats from day 5 postcoitus until day 21 postnatal results in architectural modification of cerebellar Purkinje cells, alteration of putative amino acid neurotransmitters and changes in monoamine levels in the developing rat brain up to day 21 postnatal. 6. H 2 S‐induced alterations in monoamine tissue levels observed in the developing rat brain return to control values if exposure is discontinued during development, that is, at day 21 postnatal.