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CROMAKALIM SUPPRESSES HYPERTONIC SALINE‐INDUCED RENAL VASOCONSTRICTION IN ANAESTHETIZED DOGS
Author(s) -
Ogasawara Aichi,
Hirano Takahiro,
Hisa Hiroaki,
Satoh Susumu
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02007.x
Subject(s) - cromakalim , vasoconstriction , hypertonic saline , renal function , tonicity , renal blood flow , saline , filtration fraction , anesthesia , chemistry , medicine , agonist , receptor
SUMMARY 1. Intrarenal arterial infusion of hypertonic saline (HS) transiently increased and then gradually reduced renal blood flow (RBF) in anaesthetized dogs. Glomerular filtration rate (GFR) but not filtration fraction decreased at the end of the infusion. 2. In the presence of a potassium channel opener cromakalim (0.3 μg/kg per min), HS infusion failed to reduce RBF; the initial increase in RBF was maintained throughout the infusion. Since cromakalim also prevented the decrease in GFR, HS infusion lowered filtration fraction. 3. The results suggest that cromakalim inhibits both pre‐and postglomerular vasoconstriction induced by HS infusion.