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NEUROPROTECTION IN VITRO AND IN VIVO BY CELL MEMBRANE‐PERMEANT Ca 2+ CHELATORS
Author(s) -
Tymianski Michael
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02002.x
Subject(s) - neuroprotection , neurodegeneration , in vivo , chemistry , biophysics , intracellular , in vitro , pharmacology , chelation , membrane potential , neuroscience , microbiology and biotechnology , biochemistry , biology , medicine , disease , organic chemistry
SUMMARY 1. A method of attenuating excitotoxic and hypoxic/ ischaemic neurodegeneration in vitro and in vivo using cell‐permeant Ca 2+ ‐chelating agents is described. 2. The mechanism of neuroprotection may depend on both pre‐ and post‐synaptic effects on intracellular Ca 2+ dynamics. 3. This method is unique, because it targets Ca 2+ ions, the presumed triggers of neurodegeneration, rather than a specific cellular receptor.