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EXCITOTOXICITY AS A STOCHASTIC PROCESS
Author(s) -
Dubinsky J. M.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb02001.x
Subject(s) - excitotoxicity , glutamate receptor , nmda receptor , hydrogen ion , neuroscience , chemistry , transition (genetics) , biophysics , biology , ion , biochemistry , receptor , organic chemistry , gene
SUMMARY 1. Neuronal death following excitotoxic insult appears to be a stochastic process involving transition through an intermediate biochemical state. 2. Hydrogen ion accumulation in the hours after toxic glutamate exposure may indicate that this transition has occurred.