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REGULATION OF NUCLEAR TRANSCRIPTION FACTORS BY STRESS SIGNALS
Author(s) -
Woodgett James R.,
Avruch Joseph,
Kyriakis John M.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb01995.x
Subject(s) - transcription factor , kinase , microbiology and biotechnology , activator (genetics) , serine , mitogen activated protein kinase , biology , transcription (linguistics) , mapk/erk pathway , chemistry , gene , phosphorylation , biochemistry , linguistics , philosophy
SUMMARY 1. A diverse array of stressful stimuli induces changes in gene expression via post‐translational modification of transcription factors. 2. Study of activator protein (AP‐1) transcription factor regulation has revealed a novel family of protein‐serine kinases. Molecular cloning and expression of these proteins have demonstrated their specific activation by stress stimuli such as UV irradiation, heat, ischaemia/reperfusion and metabolic toxins. 3. Dissection of the regulation of the stress‐activated protein kinases has revealed a similar but distinct mechanism to mitogen‐activated protein kinases suggesting that cellular responses to stress may partially overlap with normal growth responses and have common nuclear targets.