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EFFECTS OF ANF PROHORMONE PEPTIDES IN CONSCIOUS PRIMATES
Author(s) -
Benjamin Bruce A.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb01968.x
Subject(s) - prohormone , natriuresis , medicine , endocrinology , diuretic , npr2 , npr1 , endogeny , atrial natriuretic peptide , amino acid , chemistry , natriuretic peptide , excretion , hormone , biochemistry , heart failure
SUMMARY 1. Recent studies suggest that amino‐terminal peptides from the atrial natriuretic factor (ANF) prohormone are natriuretic. 2. The effects of pro ANF 31–67 and ANF 99–126 on renal function were studied in conscious non‐human primates ( Macaca fuscicularis ). 3. Results show that pro ANF 31–67 and ANF 99–126 are diuretic and natriuretic and that when the two peptides are given in combination sodium excretion increases in an additive fashion. 4. These results indicate that multiple peptides from the ANF prohormone are natriuretic. Furthermore, these findings suggest that the combined action of these peptides causes the natriuresis that occurs after the release of endogenous atrial peptides.