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SECRETION AND RENAL EFFECTS OF ANF PROHORMONE PEPTIDES
Author(s) -
Dietz John R.,
Vesely David L.,
Jr William R. Gower,
Nazian Stanley J.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb01966.x
Subject(s) - prohormone , medicine , endocrinology , natriuresis , atrial natriuretic peptide , secretion , chemistry , peptide hormone , plasma renin activity , stimulation , peptide , renin–angiotensin system , excretion , hormone , biology , blood pressure , biochemistry
SUMMARY 1. Atrial natriuretic factor (ANF) and pro ANF peptides appear to be secreted simultaneously from the atria in response to atrial stretch. 2. The major peptide forms secreted from rat atria appear to be ANF (pro ANF 99–126) as the primary C ‐terminal peptide and pro ANF 1–30 as the primary N ‐terminal peptide, as opposed to 1–67 or 1–98. 3. The plasma concentrations of ANF and pro ANF 1–30 are increased by acute stimulation with blood volume expansion and the plasma levels of ANF and N ‐terminal ANF prohormone peptides are chronically elevated by high salt diet. 4. Pro ANF 31–67 produces a natriuresis which is not dependent on an increase in renal cGMP excretion, decreases in plasma renin activity (PRA) or elevations in plasma ANF concentration.