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Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: FREE RADICAL TOXICOLOGY AND ANTIOXIDANT DEFENCE
Author(s) -
Winterbourn Christine C.
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb01955.x
Subject(s) - radical , antioxidant , superoxide dismutase , free radical theory of aging , chemistry , reactive oxygen species , glutathione , superoxide , biochemistry , oxygen , oxidative stress , oxidative damage , toxicology , pharmacology , enzyme , biology , organic chemistry
SUMMARY 1. A large number of compounds that have toxic effects can be metabolized to free radicals and secondary reactive oxygen species. These may be directly damaging or may affect cell function by altering regulatory mechanisms through changing redox status. 2. Protection is provided by an integrated system of anti‐oxidant defences. This includes reduced glutathione, one of the functions of which is to scavenge free radicals. It acts by channelling radicals to superoxide so that the one enzyme, superoxide dismutase, has a major control over radical reactions in the cell.