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EFFECTS OF DIETARY FIBRE ON DIMETHYLHYDRAZINE‐INDUCED CHANGES IN PROSTANOID CONCENTRATIONS IN RAT COLONIC MUCOSA
Author(s) -
Kanamori Shinichi,
Sugiyama Satoru,
Goto Hidemi,
Hayakawa Tetsuo,
Shimomura Yoshiharu,
Ozawa Takayuki
Publication year - 1995
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1995.tb01928.x
Subject(s) - thromboxane b2 , 1,2 dimethylhydrazine , prostaglandin , prostanoid , chemistry , dimethylhydrazine , thromboxane , prostaglandin e2 , medicine , endocrinology , aspirin , platelet , colorectal cancer , biochemistry , cancer
SUMMARY 1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2‐dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6‐keto‐prostaglandin F 1α , prostaglandin F 2α , prostaglandin E 2 , prostaglandin D 2 and thromboxane B 2 , were detected. 3. Four subcutaneous injections of dimethylhydrazine, 60 mg/kg every 6 days, increased the mucosal concentrations of prostaglandin E 2 and thromboxane B 2 by approximately 50%. Other prostanoids did not change significantly throughout the experiments. 4. In rats treated with dimethylhydrazine and a fibre diet a significant increase in thromboxane B 2 content was not observed, although a significant increase in prostaglandin E 2 content was observed. These effects were observed in rats fed with fibre diet over 20 days but not observed in rats fed with fibre diet over 10 days. 5. From these results and the report that aspirin use at low doses is effective in the reduction of the risk of fatal colonic cancer, inhibiting thromboxane B 2 synthesis by fibre diet might he involved in the protective effect against the occurrence of colonic cancer.