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EFFECTS OF DILTIAZEM ON [ 3 H]‐ACETYLCHOLINE RELEASE IN RAT CENTRAL NERVOUS SYSTEM
Author(s) -
Tsuda Kazushi,
Tsuda Seiko,
Masuyama Yoshiaki,
Goldstein Menek
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02552.x
Subject(s) - diltiazem , acetylcholine , stimulation , endocrinology , chemistry , cholinergic , medicine , channel blocker , central nervous system , inhibitory postsynaptic potential , pharmacology , calcium
SUMMARY 1. In the present study, we examined the effects of a Ca 2+ channel blocker, diltiazem, on [ 3 H]‐acetylcholine (ACh) release in the rat CNS. 2. Diltiazem inhibited the electrically stimulated [ 3 H]‐ACh release in a dose‐related fashion in striatal slices of Sprague‐Dawley (SD) rats. The basal release of [ 3 H]‐ACh was not significantly affected by diltiazem except at a high concentration. 3. The stimulation‐evoked [ 3 H]‐ACh release was not different between spontaneously hypertensive rats (SHR) and Wistar‐Kyoto (WKY) rats. 4. The inhibitory effect of diltiazem on the stimulation‐evoked [ 3 H]‐ACh release was significantly greater in SHR than in WKY rats. 5. The results show that diltiazem inhibited the stimulation‐evoked ACh release in the rat CNS. The pronounced effect of diltiazem in SHR suggests that the inhibition of central cholinergic activity might contribute, at least partially, to the hypotensive mechanisms of the Ca 2+ channel blocker.