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CILIARY BEAT FREQUENCY AT SIX LEVELS OF THE RABBIT AND RAT RESPIRATORY TRACT IN COW, DOG, GUINEA‐PIG, PIG
Author(s) -
Joki Susanna,
Saano Veijo
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02537.x
Subject(s) - guinea pig , respiratory tract , respiratory system , anatomy , bronchus , biology , medicine , lung , endocrinology , respiratory disease
SUMMARY 1. The ciliary beat frequency (CBF) of six animal species from six regions of the respiratory tract were measured: inferior turbinate, nasopharynx, the upper part of trachea from first to second cartilage, the lower part of trachea, main bronchus and subsegmental bronchi. Cow, pig, dog, rabbit, guinea‐pig and rat were studied. 2. There were no significant differences in the CBF values between cow, pig and dog, and the ciliary activity was essentially the same (11.3‐16.9 Hz) in all parts of the respiratory tract. 3. In the rat, the CBF was slower, especially in subsegmental bronchi (6.8 Hz). 4. In general, CBF was higher in upper than lower airways, with the exception of guinea‐pig. 5. Signal quality was the highest in guinea‐pig tissue, whereas rat tissue produced the signal with the widest variation in CBF and the highest proportion of distorted waveforms. 6. Therefore, for studying drug effects on ciliary activity, guinea‐pig seems to be a more suitable animal than the more commonly used rabbit or rat. In drug comparisons, the same part of the respiratory tract and the same animal species should be used.