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CYCLOSPORIN HYPERTENSION IN THE WISTAR RAT: ROLE OF UNINEPHRECTOMY
Author(s) -
Martin Allison,
Wong KokSeng,
Li Ming,
Turner Steven W.,
Whitworth Judith A.
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02514.x
Subject(s) - medicine , endocrinology , pharmacology
SUMMARY 1. The effects of cyclosporin A (CyA) solution (1–50 mg/kg per day), CyA powder (5–20 mg/kg per day) and vehicle, and the effects of renal mass reduction on CyA induced hypertension, were examined in conscious Wistar rats. 2. CyA solution consistently increased blood pressure at 5–20 mg/kg per day and the powder at 10–20 mg/kg per day. The vehicle had no consistent effect. 3. Both CyA solution and powder inhibited gain in bodyweight. There was no consistent effect on food intake, water intake or urine volume. Plasma sodium (Na + ), and Na + and potassium (K + ) excretion were reduced by CyA 20 mg/ kg per day. 4. Renal function was impaired by CyA powder at 20 mg/kg per day and plasma renin activity (PRA) was increased by all doses of CyA powder. 5. Thus, uninephrectomy did not potentiate CyA solution (5 mg/kg per day) induced increases in blood pressure and the effects of CyA do not appear to be a consequence of nephrotoxicity in Wistar rats.