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RENIN GENE POLYMORPHISM ASSOCIATED WITH ALDOSTERONE RESPONSIVENESS TO THE RENINANGIOTENSIN SYSTEM IN PATIENTS WITH ALDOSTERONE‐PRODUCING ADENOMAS
Author(s) -
Ballantine Donna M.,
Klemm Shelley A.,
Tunny Terry J.,
Stowasser Michael,
Gordon Richard D.
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02499.x
Subject(s) - aldosterone , renin–angiotensin system , medicine , endocrinology , polymorphism (computer science) , gene , biology , genotype , genetics , blood pressure
SUMMARY 1. Aldosterone levels in patients with unilateral aldosterone‐producing adenomas may be responsive or unresponsive to the renin‐angiotensin system, with the former often previously misdiagnosed as bilateral adrenal hyperplasia. 2. In tumours from patients in the responsive subgroup, renin mRNA is expressed in greater amounts than in tumours from patients in the unresponsive subgroup, or in normal adrenals. 3. We compared the frequency of four renin gene polymorphisms in peripheral blood DNA from the two subgroups and found significant associations between Bgl I , Taq I and Hin fI restriction fragment length polymorphisms (RFLP) and aldosterone responsiveness. 4. Allelic variation in the constitutive renin gene was associated with a specific cause of hypertension.