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RENAL EXTRACTION OF ATRIAL NATRIURETIC PEPTIDE IN UNILATERAL RENAL ARTERY STENOSIS
Author(s) -
Tunny Terry J.,
Gordon Richard D.,
Klemm Shelley A.,
Stowasser Michael,
Finn Wendy L.
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02498.x
Subject(s) - atrial natriuretic peptide , medicine , cardiology , renal artery stenosis , renal artery , stenosis , kidney
SUMMARY 1. Elevated peripheral atrial natriuretic peptide (ANP) levels were observed in 12 patients with unilateral renal artery stenosis (U‐RAS). 2. Renal extraction of ANP was higher across the affected than the unaffected kidney in U‐RAS, provided the glomerular filtration rate in the affected kidney was not severely reduced (> 12 mL/min). As ANP is a high clearance compound, reduced flow on the affected side may result in increased renal extraction of ANP. 3. When glomerular filtration rate (GFR) in the affected kidney was severely reduced (<12 mL/min), renal extraction of ANP was also reduced, possibly contributing to increased circulating ANP levels in this subgroup. 4. Overall, renal extraction of ANP was inversely correlated to peripheral ANP levels in patients with U‐RAS. This might be explained by progressive sodium retention as GFR falls leading to volume expansion and increased ANP secretion.