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DEVELOPMENTALLY REGULATED TRANSFORMING GROWTH FACTOR‐β1 ACTION ON VASCULAR SMOOTH MUSCLE GROWTH IN THE SHR
Author(s) -
Saltis John,
Agrotis Alex,
Kanellakis Peter,
Bobik Alex
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02485.x
Subject(s) - endocrinology , vascular smooth muscle , medicine , transforming growth factor , muscle hypertrophy , platelet derived growth factor receptor , platelet derived growth factor , growth factor , smooth muscle , biology , receptor
SUMMARY 1. This study examined the effects of transforming growth factor‐β11 (TGF‐β1) on platelet‐derived growth factor‐BB (PDGF‐BB)‐stimulated proliferation of vascular smooth muscle cells (VSMC) isolated from aortic tissue of I, 4 and 12 week old spontaneously hypertensive rats (SHR). 2. In 1 week old SHR, TGF‐βl inhibited by about 60% VSMC proliferation stimulated by PDGF‐BB; this inhibitory action of TGF‐β1 was absent in VSMC isolated from 4 week old, prehypertensive SHR. In contrast, TGF‐β1 potentiated by about 125% the mitogenic activity of PDGF‐BB in VSMC cultures from adult SHR. 3. Age‐dependent alterations in the action of TGF‐β1 suggests an important role for TGF‐β1 in the development of vascular hypertrophy from adolescence onwards in the SHR.