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TRANSPLANTATION STUDIES OF THE ROLE OF THE KIDNEY IN LONG‐TERM BLOOD PRESSURE REDUCTION FOLLOWING BRIEF ACE INHIBITOR TREATMENT IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Harrap Stephen B.,
Wang BaoZhong,
MacLellan Donald G.
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02480.x
Subject(s) - perindopril , blood pressure , medicine , kidney , endocrinology , transplantation , ace inhibitor , angiotensin converting enzyme , spontaneously hypertensive rat , urology
SUMMARY 1. Brief treatment with angiotensin‐converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a persistent reduction in blood pressure associated with a relatively selective reduction in renal vascular resistance. 2. To study the possible role of the kidney in this long‐term hypotensive effect, we transplanted kidneys from untreated SHR into SHR that had been treated with perindopril (3 mg/kg per day) between 6 and 10 weeks of age and also transplanted kidneys from perindopril‐pretreated SHR into untreated SHR. After transplantation, the remaining native kidney was removed so that only donor kidneys remained. 3. Untreated SHR that received kidneys from perindopril‐pretreated SHR showed an initial fall in blood pressure followed by a rapid increase in pressure, weight loss and early death. 4. The transplantation of kidneys from control SHR into perindopril‐pretreated SHR resulted in a rise in blood pressure that obviated the long‐term reduction seen normally in these animals. 5. Kidneys from perindopril‐pretreated SHR may be susceptible to the high blood pressure in untreated SHR. 6. The blood pressure increase in perindopril‐pretreated SHR that accompanies substitution of the native kidneys by kidneys from untreated SHR further supports the hypothesis that the kidney is responsible for the long‐term pressure effects following ACE inhibition in young SHR.