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COMPARISON OF SALT SENSITIVITY OF MALE AND FEMALE F 2 PROGENY FROM CROSSES BETWEEN WHY AND SHRSP RATS
Author(s) -
Nara Yasuo,
Ikeda Katsumi,
Nabika Toru,
Sawamura Makoto,
Mano Masayuki,
Endo Jiro,
Yamori Yukio
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02462.x
Subject(s) - blood pressure , medicine , endocrinology , diastole , hormone , salt (chemistry) , biology , zoology , chemistry
SUMMARY 1. The present study compared the salt sensitivity of male and female F 2 progeny obtained from crosses between Wistar‐Kyoto/Izumo rats and stroke‐prone spontaneously hypertensive rats (SHRSP A 3 b/ Izm) after salt loading for 7 months. 2. Average systolic blood pressure in male F 2 progeny was 10 mmHg higher than that of female F 2 progeny at 5 months without salt loading. 3. The blood pressure in male F 2 progeny was raised significantly 2 months after salt loading, but there was no further significant change in blood pressure even though salt loading was continued for 5 months. 4. In female F 2 progeny, however, a significant change in systolic blood pressure was observed 1 month after salt loading and there was a further significant rise in blood pressure over 6 months. 5. Angiotensin I‐converting enzyme and RR 1023 loci were strongly linked to systolic and diastolic blood pressures in the male but not the female F 2 progeny after salt loading for 7 months. 6. We therefore speculate that the hormonal difference between sexes might influence salt sensitivity in the SHRSP.