Premium
FISH PROTEIN‐RICH DIET ATTENUATES HYPERTENSION INDUCED BY DIETARY N g ‐NITRO‐L‐ARGININE IN NORMOTENSIVE WISTAR‐KYOTO RATS
Author(s) -
Jr O. G. Gutierrez,
Ikeda K.,
Nara Y.,
Deguan G. U.,
Yamori Y.
Publication year - 1994
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1994.tb02458.x
Subject(s) - medicine , nitric oxide , endocrinology , arginine , taurine , urea , dietary protein , chemistry , fish <actinopterygii> , biochemistry , biology , amino acid , fishery
SUMMARY 1. Dietary 0.023% N G ‐nitro‐L‐arginine (L‐NNA), an inhibitor of nitric oxide synthesis, induced hypertension in normotensive Wistar‐Kyoto rats (WKY). This hypertension was significantly attenuated in WKY given a fish protein‐rich diet. 2. The supplement of 2% L‐arginine given in a standard diet or a diet containing 3% taurine for drinking did not significantly affect the development of hypertension induced by L‐NNA in WKY. 3. WKY which received the standard diet mixed with 10% urea and 0.023% L‐NNA had significantly attenuated hypertension compared with WKY receiving the standard diet mixed with 10% kaolin and 0.023% L‐NNA. 4. These results suggest that the attenuation of hypertension in L‐NNA‐treated WKY rats given a fish protein rich diet may be partly caused by urea, a metabolic end‐product of protein.