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EFFECT OF DIETARY SODIUM CHLORIDE ON THE DEVELOPMENT OF RENAL GLOMERULAR AND VASCULAR LESIONS IN HYPERTENSIVE RATS
Author(s) -
Liu Dennis T.,
Birchall Ian,
KincaidSmith Priscilla,
Whitworth Judith A.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb03014.x
Subject(s) - medicine , endocrinology , blood pressure , kidney , sodium , chemistry , organic chemistry
SUMMARY1 The hypothesis that high levels of NaCl in the diet aggravates hypertension‐associated renal vascular lesions was examined in unilaterally nephrectomized deoxycorticosterone acetate treated (DOCA) and two kidney one clip (2K1C) hypertensive rats, as well as normotensive controls. 2 High NaCl diet significantly increased systolic blood pressure (SBP) in DOCA rats, but had little effect on SBP in normal control rats, and did not affect the rise of SBP in 2K1C rats. 3 High NaCl diet was associated with a higher percentage of glomerular lesions and renal arterial and arteriolar lesions in DOCA and 2K1C rats ( P <0.05). 4 Thus high NaCl intake exacerbated renal arterial and arteriolar and glomerular lesions in both DOCA and 2KlC hypertensive rats. In 2K1C rats this effect may be in part independent of blood pressure.