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CHARACTERISTIC LOCALIZATION OF α 1 ‐ and α 2 ‐ADRENOCEPTORS IN THE HUMAN KIDNEY
Author(s) -
Minamisawa Kohsuke,
Umemura Satoshi,
Hirawa Nobuhito,
Hayashi Shuichi,
Toya Yoshiyuki,
Ishikawa Yoshihiro,
Yasuda Gen,
Ishii Masao
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb01735.x
Subject(s) - rauwolscine , medulla , cortex (anatomy) , radioligand , antagonist , dissociation constant , medicine , endocrinology , chemistry , human kidney , renal cortex , alpha (finance) , kidney , biology , receptor , neuroscience , prazosin , construct validity , nursing , patient satisfaction
SUMMARY 1. The localization of α‐adrenoceptors in the plasma membranes of human kidney were investigated by radioligand binding, using an α 1 ‐antagonist, [ 3 H]‐bunazosin, and an α 2 ‐antagonist, [ 3 H]‐rauwolscine. 2. Both the maximum binding ( B max ) and dissociation constant ( K d ) of [ 3 H]‐bunazosin were greater in the cortex than in the medulla. The B max of [ 3 H]‐rauwolscine in the medulla was greater than in the cortex. 3. Thus, α 1 ‐adrenoceptors appeared to be localized predominantly in the cortex, while the α 2 ‐adrenoceptors were mainly present in the medulla of the human kidney.