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EFFECT OF POSITIVE FAMILY HISTORY OF HYPERTENSION ON THE BLOOD PRESSURE AND CATECHOLAMINE RESPONSES TO A 6 HOUR ADRENALINE INFUSION
Author(s) -
Bachmann Anthony W.,
Ballantine Donna M.,
Gordon Richard D.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb01715.x
Subject(s) - blood pressure , endocrinology , medicine , catecholamine , excretion , stimulation , epinephrine , norepinephrine , cold pressor test , urinary system , sympathetic activity , heart rate , dopamine
SUMMARY 1. The effects of 6 h infusions of adrenaline (INF‐A) or dextrose (INF‐D) and of post‐infusion cold pressor test (CPT) were compared in normal subjects, with (FH +) and without (FH ‐) a family history of hypertension. 2. Increased urinary excretion rates suggested facilitated noradrenaline (NA) release during and after INF‐A in both FH + and FH ‐. 3. Urinary adrenaline (U ADR) excretion increased during INF‐A, as expected, and was also slightly higher after INF‐A than INF‐D. 4. The effect of INF‐A on systolic blood pressure (SBP) was greater in FH — than in FH S but diastolic blood pressure (DBP) did not fall as quickly with nocturnal recumbency after INF‐A in FH +. 5. A significantly greater response in plasma NA to CPT was seen in FH + than in FH — after INF‐A. A similar trend was also seen after INF‐D. 6. Increases in DBP due to CPT were higher in FH + than in FH ‐ after both infusions. 7. This study provides evidence of increased noradrenergic activity during and after INF‐A, and also of a difference in response to sympathetic stimulation between FH + and FH ‐.