Premium
AGEING AND BLOOD PRESSURE REGULATION: DOSE‐RESPONSE RELATIONSHIPS FOR ANGIOTENSIN, BLOOD PRESSURE, ATRIAL NATRIURETIC PEPTIDE AND ALDOSTERONE IN NORMAL SUBJECTS OF VARYING AGES
Author(s) -
Finn Wendy L.,
Tunny Terry J.,
Klemm Shelley A.,
Ryan Susan J.,
Gordon Richard D.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb01714.x
Subject(s) - medicine , endocrinology , atrial natriuretic peptide , blood pressure , basal (medicine) , aldosterone , renin–angiotensin system , angiotensin ii , population , ageing , environmental health , insulin
SUMMARY 1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) but not with age. 3. This is consistent with the response of ANP to AII being mediated partly by the rise in blood pressure, independent of ageing. 4. As expected in a selected normotensive population, there was no correlation between basal blood pressure and age, but pressor slope was positively correlated with age. 5. Thus, dose‐response relationships may be an index of age‐induced alterations in pressure regulatory mechanisms.