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ANGIOTENSIN‐RESPONSIVEALDOSTERONE‐PRODUCING ADENOMAS: POSTOPERATIVE DISAPPEARANCE OF ALDOSTERONE RESPONSE TO ANGIOTENSIN
Author(s) -
Tunny Terry J.,
Klemm Shelley A.,
Stowasser Michael,
Gordon Richard D.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb01690.x
Subject(s) - aldosterone , angiotensin ii , renin–angiotensin system , medicine , endocrinology , blood pressure
SUMMARY 1. Nineteen out of 47 patients (40%) with confirmed unilateral aldosterone‐producing adenoma (APA) were responsive to low‐dose angiotensin II infusion (AH‐R), as defined by an increase in plasma aldosterone concentration of >50% over basal at 2 ng/kg per min for 60 min. 2. Seven to ten days after unilateral adrenalectomy, aldosterone was no longer responsive to angiotensin infusion in AII‐R APA (100%, n = 17). Therefore, angiotensin responsiveness resides within the adenoma in AII‐R APA. 3. The upright posture test for the differentiation of adenoma from hyperplasia was unreliable for the AII‐R APA (26%), but generally reliable in the angiotensin‐unresponsive subtype, (AH‐U APA, 96%). 4. The reported predominance of females in APA was seen in AII‐U APA (68%), but was reversed in AII‐R APA (37%).