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SHORT COMMUNICATION: EFFECTS OF NIFEDIPINE AND BAY‐K‐8644 ON THE RELEASE OF CATECHOLAMINES FROM THE DOG ADRENAL GLAND IN RESPONSE TO SPLANCHNIC NERVE STIMULATION
Author(s) -
Takeuchi Akihiko,
Kimura Tomohiko,
Satob Susumu
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb01500.x
Subject(s) - nifedipine , splanchnic nerves , catecholamine , dihydropyridine , endocrinology , medicine , splanchnic , splanchnic circulation , stimulation , norepinephrine , adrenal gland , chemistry , blood flow , calcium , dopamine
SUMMARY 1. The effects of nifedipine and Bay‐K‐8644 on the release of adrenal catecholamines were examined in anaesthetized dogs. 2. Splanchnic nerve stimulation (SNS) at 1 and 3 Hz produced frequency‐dependent increases in adrenaline (ADR) and noradrenaline (NA) output determined from adrenal venous blood. 3. Neither nifedipine (10 and 30 μg/kg, i.v.) nor Bay‐K‐8644 (10 and 30 μg/kg, i.v.) modified the SNS‐induced increases in catecholamine output. Basal catecholamine output tended to be increased and decreased by nifedipine and Bay‐K‐8644, respectively. 4. Nifedipine produced significant decreases in arterial pressure and renal blood flow rate. Bay‐K‐8644 produced a significant increase in arterial pressure associated with a decrease in renal blood flow rate. 5. These results suggest that dihydropyridine‐sensitive calcium channels do not play a major role in adrenal catecholamine release evoked by SNS.